Now that we have reached a modern age with equal rights, the discussion of female physical capability has been argued about time and time again. The answer is that there are truly physically significant differences between males and females. Males are generally stronger and faster with much higher ceiling. This means the top males are usually physically greater than the top females.
However, there is a major misconception due to the general way untrained females throw punches. Most males think they can take any strike from a female. First misconception is them thinking their chins are sturdier than they really are. Chins are very vulnerable to force, and a stiff bare fist can cause a lot of damage. A female with some technique a bit of strength can easily generate enough force to put a man out.