Throughout history there has always been the argument between what is the best form of self defense. The best form of self defense is not to let yourself get into situations and when you do, its to run very fast away. However it doesn’t hurt to have all your bases covered in case you run into a situation where you do have to use it.
Regardless, there is one single pattern in most physical altercations. Grappling eventually occurs. This happens in the sport of boxing in the form of clinch. In real life, there is no such thing as a clinch rule, so anything goes. If you want complete self defense, it is essential to learn how to defend takedowns and grapple at the least.